Johnson told reporters on a conference call Friday that the president's itinerary was not created to keep him away from protesters.
Mr Trump attacked Mr Khan over his response to the London Bridge terror attack.
On Friday evening, the Trumps will travel to Scotland, where the President owns two golf properties, Trump Turnberry and Trump Aberdeen.
They will move on to Chequers for a working lunch and bilateral talks on a range of worldwide issues, followed by a press conference.
Prime Minister Theresa May offered Trump a state visit - a pomp-laden affair usually featuring an open-top carriage trip through central London and a banquet at Buckingham Palace - when she became the first foreign leader to visit him after his inauguration in January 2017.
Now, for the important part: what's it going to look like?
Asked whether the president was seeking to avoid protesters, Mr. Johnson said: "The president is not avoiding anything".
The Stop Trump Coalition has provided a map of events and actions coinciding with the USA president's visit. The U.K. on Thursday called on the Kremlin to fill in further clues about the March attack-which Britain has blamed on Russian Federation but Moscow has denied-to help U.K. authorities keep members of the public safe.
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"All the details are still TBC but once little Donald has been run out of Britain in July, we will start to put together an itinerary - so if your community is unlucky enough to be expecting a visit from the orange sex pest, please get in touch after the 14th". He said the two leaders would discuss "the issue of the relationship with Russian Federation".
According to Vox, massive demonstrations are planned for Trump's July 13 visit.
"So when he visits the United Kingdom on Friday, we want to make sure he knows that all of Britain is looking down on him and laughing at him".
"Trump is just a four-year blip". May said he was wrong to share an anti-Islam video posted by an anti-immigrant group.
"Moral outrage is water off a duck's back to Trump, but he really seems to hate it when people make fun of him", Murray added.
The Downing Street spokeswoman said: "In every aspect of our relationship, we are seeking to deepen our special relationship and defence is one of those, and security".
Then it's off to Windsor Castle west of London, the weekend home of Queen Elizabeth II, most recently the scene of the royal wedding of Prince Harry and the American actress Meghan Markle, now known as the Duke and Duchess of Sussex.
The White House has brushed aside questions about protests during Trump's trip.