This year they have plenty of upsets again, like one region where you need to pick the 11, 12, AND 13 seeds, and another region with a 4-seed in the Final Four.
UMBC is a surprise entry into the NCAA Tournament field, after knocking off perennial tournament darling Vermont in the America East Tournament final on a stunning buzzer-beater from senior Jairus Lyles.
The University of Maryland Baltimore County pulled off the greatest upset in the event's history on Friday night, defeating Virginia 74-54 in a South Regional first-round game.
But UMBC came out firing to start the second half, building a 16-point lead and they never looked back. He also knocked down a pair of 3-pointers as UMBC built a 16-point lead. Sophomores Kyle Guy and Ty Jerome scored 15 points apiece for Virginia.
The Retrievers will now play Kansas State in the second round on Sunday. This is the program's second NCAA Tournament appearance.
Facing Virginia proved somewhat bittersweet for Odom, he indicated earlier this week, given his father's ties to the Cavaliers.
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"Unbelievable - it's really all you can say", UMBC coach Ryan Odom said.
But Hunter sat by himself on a folding chair watching a pregame layup line wearing blue sweats and a brace on his broken left wrist that has him out for the rest of the season.
WHAT ARE THE ODDS: The Cavaliers, college basketball's unanimous No. 1 team in the AP poll, enter as a 21-point favorite.
The Cavaliers had some improbable moments of their own this season on the way to a record-setting run through the ACC in which they became the first school to win 17 games in the conference and to go 9-0 on the road.
DEFENSE: Virginia has the country's best defense, surrendering just 53.4 points per game.