On Tuesday, Trump fired Secretary of State Rex Tillerson and the president has signaled in recent days that a shake-up at the top levels of his administration was not over.
McMaster was also retained at the time due to the White House's challenge attracting top talent for jobs in the administration due to Trump's "blacklist" of individuals who have criticized the President, his personality and the Russian Federation investigation, according to a senior Republican source.
Earlier this month, NBC reported that chief of staff John Kelly and Defense Secretary Jim Mattis made plans at Trump's direction to replace McMaster with auto industry executive Stephen Biegun.
However, there were indications that the Washington Post report is merely conjecture, with one Fox News reporter saying he's been told that McMaster is not being replaced.
Sanders said in a tweet.
For all of the evident disorder, Trump feels emboldened, advisers said - buoyed by what he views as triumphant decisions last week to impose tariffs on steel and aluminum and to agree to meet with North Korean leader Kim Jong Un.
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McMaster's possible replacements include former United Nations Ambassador John Bolton and Keith Kellogg, the chief of staff of the National Security Council.
And differing stances on Russian Federation might have been the last straw when it comes to McMaster's employ at the White House.
But political observers are anxious that Trump will replace those moderating forces - those who have leaned away from Trump's nationalist-leaning agenda, among other things - and install more loyalists in their place.
Amid speculation about McMaster's fate, CNN has reported that the three-star general has been in discussions with the Hoover Institution.
McMaster, a veteran of the wars in Iraq and Afghanistan as well as the 1991 Persian Gulf campaign, joined the administration a year ago after Trump dismissed his predecessor, Michael Flynn, for lying to Vice President Mike Pence.
The first one, Michael Flynn, was sacked weeks into his tenure in 2017 after misleading White House officials about his contacts with Russians.