The event is part of Premier Boxing Champions.
Ortiz will be hoping to put behind a turbulent few months behind and get the wheels in motion back in his career with a title opportunity against Wilder.
"We are thrilled to welcome the heavyweight champ back to Barclays Center for his second-consecutive fight after a big first round knockout of Bermane Stiverne in our ring last November", said Brett Yormark, CEO of Brooklyn Sports & Entertainment.
Wilder is also unbeaten in the division after 39 wins and will go into the fight with confidence following a crushing first round defeat of Bermane Stiverne.
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Also, the dollar fell in a broad sell-off after a report that China was ready to slow or halt its USA treasury purchases. That level would be the highest annual average on record, surpassing the previous record of 9.6 million b/d set in 1970.
Undefeated American heavyweight Deontay Wilder will defend his World Boxing Council crown in March against unbeaten Cuban contender Luis Ortiz in NY, promoters announced Friday.
The "Bronze Bomber" was due to take on Ortiz in November, only for the Cuban to test positive for a banned substance.
Anthony Joshua says he is happy to fight Deontay Wilder or Joseph Parker next as long as it is for a championship belt.
Britain's Anthony Joshua, who holds the IBF and WBA world heavyweight belts, is in talks with WBO champion Joseph Parker of New Zealand over a potential fight at Cardiff's Principality Stadium on 31 March.