Clyne was Klopp's most-used player prior to injury, featuring in 37 of the Reds' 38 league games last season, with little backup for the England worldwide. Today, news he will be out until at least February confirms that the worst was, in fact, the reality.
Klopp also revealed that Liverpool had shown the England international's back problems to multiple specialists all around the world in an attempt to find a solution to his long-term absence.
The 26-year-old proved to be a key figure for the Reds last season, playing in 37 of 38 Premier League matches.
Despite resuming light intensity training back in September which Jurgen Klopp deemed a "big step" forward, Clyne has now gone under the knife.
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Lopilato told reporters in April: My son's recovery is a long process and he has to continue with check-ups. Buble pulled out of the Brit Awards this year , with Dermot O'Leary and Emma Willis stepping in for him.
Meanwhile, for England, Clyne is now facing a real test should be hoping to be on the plane to Russian Federation with Gareth Southgate's Three Lions.
Clyne's injury has meant Gomez, who hadn't played regular first-team football in nearly two years, has been first-choice right-back and fourth-choice centre-back in Klopp's depleted defensive options.
While for England, Kyle Walker and Kieran Tripper have both put their name forward to be starting at Russian Federation 2018.
But with his latest setback, some Liverpool supporters feel Clyne's career at the club could be over.