The incident occurred at the Pasquotank Correctional Institute in Elizabeth City, where fires were set in the prison's sewing plant, the North Carolina Department of Public Safety said in a tweet Thursday afternoon.
The fire had been extinguished by about 5 p.m., according to the Department of Public Safety.
Elizabeth City's Sentara Albemarle Medical Center received six people requiring treatment, hospital spokesman Peter Sengenberger said. "Several employees injured." It added there would be "more info when available".
According to WNCN, fires were set at the facility and three nearby schools are on lockdown.
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Officials were responding Thursday to an attempted prison break at Pasquotank Correctional Institute in North Carolina, where multiple people had been injured.
Students were dismissed, but those who ride the bus were required to have a parent at home when the bus arrived. Northside Elementary, Elizabeth City Middle, and Pasquotank County High School were placed on lockdown as a precaution.
The institution is a high-security prison for men and has capacity to hold almost 900 inmates, according to its website. However, extra precautions were still being taken to securely transport students home. Elizabeth City is about 50 miles (80 kilometers) south of Norfolk, Virginia, and near North Carolina's Outer Banks.