This is the first time Germany have qualified for a World Cup finals with a ideal record and they are unbeaten in their last 16 games.
To compound matters, Azerbaijan continued to play and scored an equalising goal in the first half.
"It will be hard to win the World Cup for a second time".
"One makes a mistake if one sets this qualification as a benchmark", he said.
Loew's initial plans to use the game as a first test en route to their title defence went out the window with first-half injuries to defenders Niklas Suele and Shkodran Mustafi.
'With Mustafi it seems that it is muscle tear or some muscle fibre tear, ' he said after the match.
Liverpool's Emre Can scored a powerful effort to finish off Germany's rout of Azerbaijan in style.
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The hosts got off to a dream start when Goretzka showed great technique by netting with his heel and his back to goal on eight minutes.
The 24-year-old pulled up clutching his right thigh in the 36th minute of the match just before Azerbaijan scored their goal through Ramil Sheydaev, with coach Joachim Löw later confirming he sustained a suspected muscle injury.
But Wagner put Germany back in the lead on 54 minutes thanks to Hawk-Eye.
Azerbaijan deservedly levelled on 34 minutes when Sheydaev sprinted clear of Mustafi - who pulled up injured.
Yet his team quickly finished off the game with Wagner grabbing his fifth goal in his fifth worldwide in the 54th minute and Antonio Ruediger scoring 10 minutes later.
Mustafi was then carried off by the Germany medical team and replaced by Matthias Ginter.