It was the Nittany Lions' first kickoff return for a score since Chaz Powell had a 95-yarder against Indiana State in 2011. It marks the first time since 2001 that Penn State has had two special teams touchdowns in the same game.
Best call: Barkley's option pass to DaeSean Hamilton, which went for a 16-yard touchdown in the fourth quarter.
Barkley returned the game's opening kickoff 98 yards for a touchdown and finished with 221 yards to pad his Heisman Trophy resume.
Worst pass: Penn State cornerback Amani Oruwariye intercepted Peyton Ramsey's pass intended for Taysir Mack.
The junior quarterback passed for 315 yards, had three touchdowns (one rushing), and one interception.
"Penn State's running back continues to find new ways to amaze", CBS Sports' Ben Kercheval writes.
Best block: Barkley threw the lead block on McSorley's 1-yard touchdown run in the first quarter. Scott scooped it up and returned it 13 yards to put Penn State up 21-0 less than 10 minutes in.
IN fumbled it away again when Irvin Charles ripped the ball out of punt returner J-Shun Harris' hands.
Most telling statistic: Penn State scored 21 points off IN turnovers. "So whenever you can say you're the all-time leader at Penn State that's pretty special". He also caught four passes for 51 yards.
Berks report: Guard Michal Menet (Exeter) saw action on special teams for Penn State. "Obviously Saquon is going to draw a lot of attention when he has the ball in hands so the last thing people are going to expect is for him to throw the ball so that play just worked out perfectly". He did not return. This return set the tone for Penn State football's blowout victory on Saturday.
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Penn State senior offensive tackle Andrew Nelson sat out with an undisclosed injury.
Before Saturday's IN matchup, wide receiver DaeSean Hamilton knew right where he was slotted on Penn State's all-time career receptions list.
11 - Consecutive home wins for Penn State. The Hoosiers defense sold out in an effort to keep Saquon Barkley from beating them.
Streaking: McSorley hit Hamilton on a fade for a score with less than a minute to go in the first half, marking the 20th consecutive game he threw at least one TD pass. McSorley's streak almost ended a week ago until he hit Juwan Johnson with the game-winner at Iowa.
After being used sparingly on special teams in his first two years with the Nittany Lions, James Franklin chose to make Barkley the No. 1 kick returner in 2017.
Before the season began, Penn State's Saquon Barkley said he wanted to become so proficient at studying film that, if needed, he could play quarterback.
On Saturday, Davis was 1-for-3 with another blocked kick after he had a crucial kicked blocked a week ago at Iowa.
Redshirt freshman Will Fries made the second start of his Penn State career, lining up at right tackle.
Penn State practiced that pass play this week, and Barkley said it didn't go so well.