The dual Oaks victor also landed the King George VI and Queen Elizabeth Stakes earlier this year and after being handed a good inside draw for Sunday's big race, bookmakers have made her the odds-on favourite at around the 10-11 mark although you can get evens at Paddy Power and Betfred at the time of writing.
"She's very special and has incredible ability", he said. She was timed in a good 2:28.69 for the 1 1/2 miles over soft ground.
With record-breaking jockey Frankie Dettori patiently biding his time, Enable (4-5) cruised past pace-setting rivals like a souped-up sports auto using the fast lane to blow past family sedans. Little wonder there was a quiet sense of joy once her trainer announced the possibility of her staying in training and doing it all over again when the Arc returns to Longchamp next autumn. As if the pressure of riding one of the best fillies of recent times is enough to bear, the 46-year-old could surpass the tallies of Jacques Doyasbere, Freddy Head, Yves Saint-Martin, Pat Eddery, Olivier Peslier and Thierry Jarnet if he converts what many see as the proverbial penalty kick.
Enable had gone into Europe's most prestigious race off the back of four straight Group One victories and the John Gosden-trained horse did not disappoint.
O'Brien, who trained the first three home in the European showcase 12 months ago, will be represented by Idaho, Winter, Order Of St George, Capri and Seventh Heaven in the 18-horse line-up.
Gosden revealed he had no plans to run Enable again this season, including in the Breeders' Cup in the United States.
A dual Guineas victor, she has landed four Group One prizes this season but was defeated narrowly in a mile contest last time out.
"She is the best filly I've ever ridden", said Dettori, who celebrated in his usual fashion, leaping from the irons into the winner's enclosure.
"I had a lovely position throughout, tracking Enable", he said.
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Reflecting on the performance, he added: "She showed an impressive turn of foot and acceleration to kill the field". "She's got plenty of speed so the drop back to five will be no problem".
Paddy Power went 3-1 to win a second Arc but Sun Bets gave punters a taster tempter offering 5-1 for the double. He's pretty good for an old jock!
"We have been delighted with her at home", Appleby told ITV Racing.
Just as she had done all summer, Enable cranked up the revs within a heartbeat and skipped into the lead inside the final two furlongs.
"She enjoys her work".
The odds-on favourite Enable is favourably drawn in gate 2.
Enable is a 3-year-old Juddmonte Farms homebred daughter of Nathaniel, out of the Sadler's Wells mare Concentric. The fourth dam, Fleet Girl, was bought by Prince Khalid Abdullah when he acquired the bloodstock of Dr Schnapka, Ferrans Stud, in 1982. She and Clemmie, victor of Saturday's Group 1 Cheveley Park at Newmarket, England, are under consideration for the Juvenile Fillies Turf. Apogée, the second dam, won the Prix de Royaumont (Group 3).
The Newmarket trainer said: "She's very special".